|
KMID : 0363320000210030433
|
|
Journal of Korean Oriental Internal Medicine
2000 Volume.21 No. 3 p.433 ~ p.441
|
|
|
The Effects of Yukmijihwang-tang, Taeksa-tang, Silbi-um on Mesangial cell Proliferation, Fibronectin Synthesis, MHC-class II Expression
|
|
Lee Jin-Sin
Ahn Se-Young
Doo Ho-Kyung
|
|
|
Abstract
|
|
|
Objective : To analyze the effects of Yukmijihwang-tang, Taeksa-tang, Silbi-um on mesangial cell proliferation, fibronectin synthesis and MHC-class II expression.
Methods : Laboratory studies were performed with the method of surface enzyme immunoassays or flow cytometry after addition of peripheral blood mononuclear cells(PBMC) supernatants treated with medications using the cultured human mesangial cells.
Results : 1. Silbi-um produces more suppressive effect than control group and hydrocortisone group on the mesangial cell proliferation. In Yukmijihwang-tang, Taeksa-tang and Silbi-um, mesangial cell proliferation significantly decreased than in hydrocortisone group 2. In the ’without fetal bovine serum’ study, Yukmijihwang-tang take more suppressive effect than Control group on the fibronectin synthesis. In the ’with fetal bovine serum’ study, Yukmijihwang-tang, Taeksa-tang, Silbi-um all have suppressive effect, but it hasn’ t any statistical significance. 3. Yukmijihwang-tang, Taeksa-tang, Silbi-um all have a suppressive effect on the MHC-class II expression.
Conclusions : Herb medicine generally show a suppressive effect on the suppression of the mesangial cell proliferation, fibronectin synthesis and MHC-class II expression.
|
|
|
KEYWORD
|
|
|
Yukmijihwang-tang, Taeksa-tang, Silbi-um, Mesangial cell proliferation, Fibronectin synthesis, MHC-class II expression
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|